Laryngoscopy and endotracheal intubation lead to tachycardia and hypertension due to sympathetic response. So, anaesthesiologist is always worried about this pressor response which leads to abnormal circulatory reaction which may be severe or prolonged and may cause myocardial ischemia, ventricular arrhythmia and cerebral haemorrhage. The present Prospective randomized double blinded study was carried out in 60 Patients admitted for surgeries under general anaesthesia in department of surgery, ENT, orthopaedics at NMCH Raichur selected for variouselectivesurgical procedures with American Society of Anaesthesia (ASA) physical status I and II. We included total 30 subjects in Group D i.e., Dexmeditomedine and in Group F i.e. Fentanyl. When we compared the baseline parameters between two groups, the difference was not statistically significant (p>0.05). Means SPO2 and HR at 1 minute was significantly lower in Group D (99.84±0.47 and 87.12±9.39) as compared to Group F (100±0 and 91.72±7.23). Mean SBP, DBP, MAP and HR in Group D was significantly lower as compared Group F at 1 minute, 2minute, 3 minute, 4 minute, 5 minute and 10 minutes after intubation (p<0.05). Dexmedetomidine is superior and better drug compared to fentanyl to reduce haemodynamic response i.e., attenuation of pressor response to laryngoscopy and tracheal intubation with single premedication dose.