Background: Obesity has well-known negative effects, such as comorbid conditions including dyslipidemia, type 2 diabetes, and hypertension. The present study was conducted to assess occurrence of dyslipidemiain patients with gastrojejunostomy. Materials & Methods: 45 patients who underwent gastrojejunostomy of both genders were selected. Cases were kept in group I and age matched control in group II. Details of weight, presence of co-morbidities like DM, dyslipidemia and cirrhosis were obtained. Results: There were 22 males and 23 females in group I and 21 males and 24 females in group II. BMI was 19.3 kg/m2 in group I and 20.1 kg/m2 in group II. The occurrence of diabetes was seen in 3 in group I and 8 in group II, dyslipidemia in 2 in group I and 6 in group II, cirrhosis 5 in group II and hypertension 3 in group I and 9 in group II. The difference was significant (P< 0.05). In group I and group II, mean WBC count (cells/mm3) count was 9188.2 and 8124.5, Hb (gm/dL) was 9.5 and 10.2, ESR (mm/hour) was 30.5 and 23.2, RBS (mg/dL) was 98.4 and 95.2, triglyceride (mg/dL) was 335.4 and 164.3, cholesterol (mg/dL) was 256.2 and 210.6 and LDL (mg/dL) was 164.2 and 150.0 respectively. The difference was significant (P< 0.05). Diagnosis was dyspeptic symptoms in 27, anaemia in 8, malena in 5, pain abdomen in 3 and primary malignancy in 2 cases. Conclusion: In patients with GJ, the prevalence of obesity, diabetes, and dyslipidemia is reduced. The complicated changes in gut hormones brought on by GJ's food bypass may contribute to the lower prevalence of DM and obesity.