Introduction: Histopathology of cutaneous lesions plays an important role in the diagnosis of many skin diseases. Dermatologists are able to recognize most skin disease based on their appearances, anatomic distributions and behaviour. However, in some criteria do not allow a conclusive diagnosis to be made and a skin biopsy is taken and its histopathological description and diagnosis with differential may aid to certainty to the specific outcome. Aims & Objectives: To study the histopathological findings in various skin disease and to correlate the clinical findings with histopathological features of various lesions of the skin and to aid in the diagnosis. Material and Methods: This was a prospective study conducted for a period of two years in department of pathology were consecutive skin biopsies in 133 patients were received from department of Dermatology of G K General Hospital, Gujarat Adani institute of medical sciences, Bhuj. Gross examination done and H&E stained section were studied and analysed according to published protocol. Results: Histopathological correlation was found in 95 (71%) out of 133 cases. Most common clinical presentation was papulosquamous disease(36%) and commonest Histopathologic diagnosis was lichenoid reaction in 23%, patients with overall male to female ratio of 3:2. Maximum cases belonged to age group of 21-30 years. Leprosy was found in 6% patients. In the bullous lesion most common finding was Hailey Hailey disease found in 2% patients. In 38 patients clinical diagnosis was not proved by microscopy. Conclusions: Despite the fact that a plethora of modern techniques have been developed and utilized in the diagnosis of skin disease, dermatologists still rely vastly on biopsy for diagnostic purpose as it was performed and selected skin biopsy taken in order to confirm their suspected diagnosis, and the histological perspective proves to be both helpful and reliable in the majority of cases.