Background: Laparoscopic surgery has revolutionized the treatment of abdominal wall hernias, offering numerous advantages over traditional open approaches, such as reduced postoperative pain, faster recovery, and minimal scarring. The aim of this study was to compare the outcomes of absorbable versus non-absorbable tackers for mesh fixation in laparoscopic midline anterior abdominal wall hernia repair, focusing on postoperative pain, complications, and patient satisfaction.Materials and Methods: This prospective, randomized clinical study was conducted at a tertiary care hospital. A total of 100 patients diagnosed with midline anterior abdominal wall hernias were randomly assigned into two groups: Group A (Absorbable Tacker) and Group B (Non-absorbable Tacker), with 50 patients in each group. The primary outcomes included postoperative pain (measured using the Visual Analog Scale at 24 hours, 7 days, and 1 month), complication rates (wound infection, seroma, hematoma, mesh migration, recurrence), and patient satisfaction at 1 month. Data were analyzed using appropriate statistical tests.Results: There were no significant differences between the two groups in terms of baseline characteristics, surgery duration, intraoperative complications, or mesh size. Postoperative pain scores showed no significant differences between the groups at 24 hours, 7 days, and 1 month. The complication rates, including wound infection, seroma, hematoma, mesh migration, and recurrence, were similar between the groups. Patient satisfaction was also high, with 94% in Group A and 92% in Group B, showing no significant difference.Conclusion: The study concluded that there were no significant differences between absorbable and non-absorbable tackers for mesh fixation in laparoscopic hernia repair. Both techniques resulted in similar postoperative outcomes regarding pain, complications, and patient satisfaction. Either tacker type can be considered safe for this procedure.