Background: Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus, often leading to lower limb amputations. Wagner’s Classification is widely used for grading DFUs based on depth, infection, and gangrene severity. This study aims to evaluate the clinical profile, microbial spectrum, treatment modalities, and outcomes of diabetic foot patients based on Wagner’s Classification. Methods: A prospective observational study was conducted on 67 patients with diabetic foot ulcers. Data on demographic details, clinical presentation, microbial isolates, treatment strategies, and outcomes were recorded. Patients were classified according to Wagner’s system and managed accordingly. Follow-up was done at 1, 4, and 12 weeks to assess healing status. Results: Males (65.7%) were predominantly affected, with the highest incidence in the 40–50 years age group (29.9%). Ulcers (53.7%) were the most common presentation. The microbial analysis identified Staphylococcus aureus (28.4%) and Pseudomonas (23.9%) as the predominant pathogens. Most cases were Wagner’s Grade II (43.3%), followed by Grade I (25.4%) and Grade III (16.4%). Treatment involved debridement (37.3%), antibiotics (26.9%), and amputation (11.9%). Complete healing improved from 7.5% at 1 week to 53.7% at 12 weeks. Factors significantly influencing healing included age <60 years, non-smoking status, and blood sugar <200 mg/dL (p<0.001).Conclusion: Wagner’s Classification plays a vital role in guiding diabetic foot management. Early intervention, glycemic control, and appropriate infection management significantly improve outcomes and reduce amputation rates.