INTRODUCTION: A drain is a tube designed to facilitate the removal of fluid or air that may accumulate at a surgical site or within a wound. This drainage is crucial as it aids in the healing process by preventing fluid build-up, which can lead to infection or other complications. AIMS AND OBJECTIVES: The objective is to evaluate the efficacy of different suction drains in minimizing seroma development in patients following mastectomy. Additionally, the study aims to assess the effectiveness of a commercially available suction drain in decreasing seroma formation in post-mastectomy patients. MATERIALS AND METHODS A prospective non-randomised hospital-based observational study. Duration of Study: August 2022 - June 2024. OBSERVATIONS AND RESULTS This study is a prospective non-randomised hospital-based observational study conducted over a period of two years, from August 2022 to June 2024. It includes a total of 100 female patients who underwent modified radical mastectomy with drain insertion at MGM Warangal. DISCUSSION: In the Present study, there are a total of 100 cases. The ages range from a minimum of 35 to a maximum of 80, with an average age of 50. CONCLUSION Commercial suction drains are more effective than indigenous suction drains in reducing seroma formation post-mastectomy. The peak incidence of mastectomy cases is observed in the 41-50 age group, where the efficiency of commercial drains can provide significant benefits.