Introduction: In developing countries, chronic kidney disease (CKD) associated with anaemic condition is the most common public health problems. Gradually the progression of this condition, development of haematological abnormalities including iron related defect. This iron related defect may further increase the morbidity and mortality in these patients. Earlier detection and correction of anaemia may be helpful in preventing the progression of the diseases and its other adverse outcomes. Aim and Objective: The aim of the study is to identify the iron status in the Chronic Kidney Disease Patients. Methods: The present study was designed to Collect the laboratory data of iron profiles in CKD patients. For this purpose, there were collected 150 adult diagnosed CKD subjects data and consider as cases similarly 150 data were collected and consider as control who were not suffering from CKD. Serum iron, TIBC, serum ferritin level and serum creatinine were estimated by standard laboratory techniques. Statistical data were analyzed by using SPSS 21.Results: The mean total serum iron 58.6μg/dl, Total Iron Binding Capacity (TIBC) 238 μg/dl, serum ferritin 438.62 μg/dl, and serum creatinine level 8.35 mg/dl respectively and showed P value significant. When the serum iron profile of individuals was analyzed, majority (54.25%) of the patients were found to have acute phase reaction.Only some of the patients showed microcytic anemia in peripheral smear. The primary aetiologies of CKD were Diabetes (42%), Hypertension (24%) and Acute kidney disease (16%). Conclusions: Anaemia is one of the commonest and earliest manifestations in CKD patients. All CKD patients had early detection and correction of anemia so that improved renal disease progression and survival rate of the patients.