Aim: Isoflurane anesthesia has been associated with higher serum levels of catecholamines and cortisol compared to propofol anesthesia, suggesting that the stress response is lower with propofol. Hence; the study assessed the Effects of Propofol and Isoflurane on Blood Glucose during Abdominal Hysterectomy in Diabetic Patients. Materials and methods: A study was conducted on 25 women aged 30 to 65 years with ASA physical status II undergoing elective abdominal hysterectomy under general anesthesia. Patients with renal failure, severe liver disease, a history of allergy to propofol, or those on medications affecting blood glucose or insulin release (e.g., steroids, β-blockers) within a week before surgery were excluded. Blood glucose levels and insulin infusion rates were statistically analyzed using SPSS version 15, employing t-tests and repeated measures analysis, with significance set at P<0.05. Results: No significant difference in blood glucose levels between the two groups from the preoperative phase to the second 30-minute intraoperative period. At the third 30-minute mark (FBS5), Group I (Isoflurane) showed a significant rise in blood glucose levels compared to Group P (Propofol), suggesting a possible effect of isoflurane on glucose metabolism. Conclusion: Diabetes is a multifaceted metabolic disorder marked by hyperglycemia, which is a physiological state characterized by persistently high levels of glucose in the bloodstream.Propofol may provide better intraoperative glucose stability compared to isoflurane.