Background: Change in the learning environment can affect student’s learning outcome. The teaching by onscreen classes or e-learning has entirely changed the learning environment. This study was conducted to find the Knowledge, attitude and Perception of MBBS students towards teaching through onscreen and conventional classes. Methods: This observational, questionnaire based, cross sectional study was conducted on MBBS students of all Professional years of 2015 to 2019 studying in medical college of Northern India. The 19 item questionnaire was sent to the students by electronic mode through Google forms. The completely filled questionnaire was accepted and the responses were recorded and analyzed using SPSS version 21 software. The data was presented in percentage. Results: 400 students had given their informed consent and submitted the completely filled Questionnaire. The mean age of the participant was 20.87±1.407. 70.5% (282) students used phone, 2.75% (11) used Laptop and 26.75% (107) used both to attend online classes. Majority students found reading, understanding and concentration easier through conventional teaching and also rated it ‘good’ for time duration, interactions and adherence to classes. 166(41%), 148(37%), 168(42%) students were moderately satisfied through conventional classes while 151(37.8%), 144 (36%), 146(36.5%) were moderately satisfied through onscreen classes in respect to reading, understanding & learning and interaction with teacher respectively. Conclusions: We concluded that students preferred conventional teaching and their level of satisfaction was higher in reading, understanding, concentrating, interacting with teacher and adherence. Technical issues like poor internet connectivity, lack of skill; psychological issues like maintaining positive attitude, distraction in home environment and health issues like headache, strain in eyes and blurring of vision were the various issues and barriers reported by the students while attending online classes.