Thalassemia syndromes are heterogeneous because of the various possible mutations which affect the human globin chain loci, such as globin chain initiation, translation, termination and also gene deletion. All enrolled children were taken detailed clinical history including age at first blood transfusion, number of blood transfusion, duration of iron chelation therapy and General physical examination findings were recorded on a predesigned proforma. Before blood transfusion, for all enrolled children one blood sample was sent for Serum ferritin level and another sample for pre-transfusion Hb. Serum ferritin level was measured by electrochemi-luminescence technique using Cobas 6000 analyser. In the study, all children (100%) presented with Easy Fatigability and progressive pallor. All children except 2 (4.4%) had presented with cough secondary to URTI. None of the children presented with rapid breathing, chest in drawing, Chest pain. On per abdomen examination all children had hepatomegaly (100%) and 34 children (75.5%) had splenomegaly, remaining 11(24.5%) children were splenectomised.