Outcome of patients suffering from mental illness largely depends on their adherence to the medication which is very difficult to achieve. Amongst multiple factors, internalized stigma related to mental illness that they suffer, and their own personal wellbeing seems to play a major role in maintaining adherence to the medications. This study aims at studying the effect of these two factors on adherence to medication. Aim of the study is to study the level of medication adherence and its relationship with internalized stigmaas well as mental well-being amongst follow up patients. After taking written informed consent and Institute Ethical Committee permission datacollected from follow up patients on treatment since at least 2 months and attending the outpatientdepartment of psychiatry in C. U. Shah Medical College and Hospital through Structured Proforma: Participant’s Profile, Morisky Green Levine Scale (MGVS), Internalized Stigma ofMental Illness Inventory (ISMI), Mental Health Inventory (MHI) was analyzed using SPSSversion 16.Amongst 89 follow up patients, medication adherence was medium (67.5%) and low(32.5%) level and it had strong negative association with global scores of ISMI (χ2=7.6, γ=- 0.78, P