Aim: This study aimed to assess menopause-related health problems and the quality of life among menopausal women residing in urban slums of Western Uttar Pradesh, focusing on the prevalence of symptoms and their association with socioeconomic and lifestyle factors. Materials and Methods: A cross-sectional observational study was conducted among 120 menopausal women aged 40-60 years from urban slums. Participants were selected using house-to-house surveys based on predefined inclusion and exclusion criteria. Data were collected using a structured, pre-tested Menopause-Specific Quality of Life (MENQOL) questionnaire and a semi-structured survey covering socio-demographic details, reproductive history, lifestyle factors, and health conditions. Results: The majority of participants were 46-50 years old (33.33%), and 50.00% were housewives. 58.33% belonged to low-income groups, and 20.83% were illiterate. The most commonly reported symptoms were joint pain (50.00%), fatigue (45.83%), hot flashes (41.67%), and mood swings (37.50%). Psychosocial symptoms, including anxiety (31.67%) and depression (25.00%), were significantly associated with socioeconomic status (p<0.05). 35.00% of women reported decreased libido, while 29.17% had vaginal dryness. Diabetes (20.83%), hypertension (29.17%), and osteoporosis (16.67%) were the most prevalent co-morbidities. Lower socioeconomic status was significantly associated with more severe menopausal symptoms (p<0.05). Conclusion: The study highlights the high burden of menopause-related symptoms among women in urban slums, with socioeconomic disparities exacerbating symptom severity. Poor lifestyle habits, inadequate healthcare access, and limited awareness further impact their quality of life. Targeted health interventions, awareness programs, and improved healthcare access are crucial for addressing the challenges faced by menopausal women in low-income settings.