Background: Laparoscopic cholecystectomy (LC) has become the gold standard for the surgical treatment of gallbladder diseases, particularly symptomatic cholelithiasis. To compare the outcomes of Single Incision Laparoscopic Cholecystectomy (SILC) and Conventional Four Ports Laparoscopic Cholecystectomy (C4PLC) in terms of intraoperative parameters, postoperative recovery, complications, and patient satisfaction.Material and Methods: This comparative study included 100 patients diagnosed with symptomatic cholelithiasis, randomly assigned into two groups: SILC (n=50) and C4PLC (n=50). Preoperative evaluations included clinical history, examination, routine blood investigations, liver function tests, and ultrasonography. SILC was performed using a single umbilical incision with a specialized port, while C4PLC followed the standard four-port technique. Operative time, blood loss, conversion to open surgery, postoperative pain (VAS score), analgesic requirements, hospital stay, complications, and patient satisfaction were assessed. Statistical analysis was performed using SPSS, considering p<0.05 as significant.Results: Baseline characteristics were comparable between the two groups. The SILC group had a significantly longer operative time (55.3 ± 12.6 min vs. 42.8 ± 9.4 min, p<0.001) and higher blood loss (45.2 ± 10.8 mL vs. 30.6 ± 8.9 mL, p<0.001). Pain scores were significantly lower in SILC at 6 hours (5.8 ± 1.2 vs. 6.5 ± 1.0, p=0.03) and 24 hours (3.2 ± 0.9 vs. 3.8 ± 1.0, p=0.04). The SILC group required fewer analgesic doses (3.5 ± 1.1 vs. 4.2 ± 1.3, p=0.02) and had a shorter hospital stay (2.1 ± 0.5 days vs. 2.5 ± 0.6 days, p=0.01). Postoperative complication rates were similar between both groups. SILC patients reported significantly higher satisfaction (8.5 ± 1.2 vs. 7.8 ± 1.4, p=0.02) and better cosmetic outcomes (9.2 ± 0.8 vs. 7.5 ± 1.1, p<0.001).Conclusion: SILC is associated with reduced postoperative pain, shorter hospital stays, and better cosmetic outcomes but has longer operative times and higher intraoperative blood loss compared to C4PLC. Both techniques have comparable safety profiles. SILC can be a preferred approach for patients prioritizing cosmesis and minimally invasive surgery.