Aim: This study aims to evaluate and compare the hemodynamic stability of spinal anesthesia (SA) versus general anesthesia (GA) in patients undergoing interventional radiology procedures. Materials and Methods: A total of 110 patients scheduled for elective interventional radiology procedures were enrolled in this prospective comparative study. The patients were divided into two groups: the SA group (n = 55) and the GA group (n = 55). Hemodynamic parameters, including heart rate (HR), mean arterial pressure (MAP), and oxygen saturation (SpO₂), were monitored preoperatively, intraoperatively, and postoperatively. Primary outcomes included variations in HR and MAP, as well as the incidence of hypotension and bradycardia. Secondary outcomes included vasopressor use, postoperative nausea and vomiting (PONV), pain scores, recovery time, and hospital stay. Results: The study found that the SA group exhibited significantly lower HR and MAP compared to the GA group at multiple intraoperative time points. The incidence of hypotension was higher in the SA group (30.91%) compared to the GA group (18.18%). Postoperative pain scores were significantly lower in the SA group at 1, 6, and 24 hours postoperatively (p < 0.05), and the SA group also had a lower incidence of PONV (10.91%) compared to the GA group (21.82%). Recovery time and hospital stay were shorter in the SA group (45.12 ± 5.34 minutes and 2.87 ± 0.76 days, respectively) compared to the GA group (60.34 ± 6.12 minutes and 3.65 ± 0.89 days). Conclusion: Spinal anesthesia offers superior postoperative analgesia, reduced PONV, and faster recovery compared to general anesthesia in patients undergoing interventional radiology procedures. However, it is associated with greater intraoperative hemodynamic suppression, requiring closer monitoring and more vasopressor support. SA may be the preferred technique in cases where improved recovery and pain management are desired, with careful management of hemodynamic stability.