Background: Otitis externa is an inflammatory infection of the external ear canal that might lead to a very severe disease namely necrotizing otitis externa (NOE). However, existing literature data is scarce in the Indian scenario for NOE. Aim: The present study aimed to assess the clinic-microbiological profile of subjects with necrotizing otitis media in subjects with diabetes mellitus (DM). Methods: The present study assessed 60 subjects who had confirmed diagnosis of otitis externa with diabetes mellitus. In all the included subjects, clinical picture and microbiological profile were assessed on the collected samples. The data gathered were analyzed statistically for results formulation. Results: The studyresults showed that among 60 subjects assessed in the study, there were 36 male and 24 female subjects that had diabetes mellitus with otitis externa. The mean age of the study subjects was 60.51±9.6. In all the study subjects, edema of the external auditory canal, otorrhea, and severe night otalgia were seen. In eight cultures, no growth was seen, whereas, in 26 subjects, pus culture showed pseudomonas sp. And 10 subjects showed mild conductive hearing loss. In 4 among 60 subjects, two subjects had facial nerve involvement leading to facial nerve palsy, and the other two depicted facial nerve palsy with glossopharyngeal nerve injury on CT (computed tomography) findings. Conclusions: The present study concludes that necrotizing otitis externa is common in subjects with diabetes mellitus mainly in subjects aged 60-80 years. The most common cultured microorganism seen in study subjects was Pseudomonas species.