Background: One common technique for renal therapy is laparoscopic renal surgery (LRS), which can be performed via the retroperitoneal or transperitoneal approach. However, moderate-to-severe pain persists in the early postoperative phase even though LRS causes less surgical trauma than open surgery. The present study assessed efficacy of analgesia with QLB in unilateral laparoscopic renal surgeries. Materials & Methods: 70 patients of unilateral laparoscopic renal surgeries of both genderswere divided into 2 groups of 35 each. Group I received QLB and group II received no block at the end of surgery. A 1 mg bolus and a 10-minute lockout interval were used while administering morphine via a patient-controlled analgesia pump. The amount of morphine consumed overall was noted. Both groups received standardized general anesthesia. A Visual Analogue Scale (VAS) was used to measure the pain. Results: Group I had 21 males and 14 females and group II had 20 males and 15 females. The mean age was 39.2 years in group I and 41.7 years in group II, height was 167.2 cm in group I and 166.5 cm in group II, weight was 71.4 kgs in group I and 73.1 kgs in group II, duration of surgery was 45.3 minutes in group I and 46.2 minutes in group II, ASA grade I was seen in 20 in group I and 18 in group II, grade II 14 in group I and 15 in group II, and grade III in 1 and 2 in group I and II respectively. Total morphine consumption was 3.7 mg in group I and 9.4 mg in group II and duration of post- operative analgesia was 1120.3 minutes in group I and 149.6 minutes in group II. The difference was non- significant (p> 0.05). Type of surgery performed was laparoscopic pyelolithotomy seen in 15 in group I and 16 in group II, laparoscopic pyeloplasty 8 in group I and 9 in group II and laparoscopic nephrectomy 12 in group I and 10 in group II. The mean VAS was 2.9 in group I and 3.5 in group II. The difference was non- significant (p> 0.05). Conclusion: After laparoscopic renal procedures with ultrasound-guided QLB, there was a decrease in the use of opioids.