Original Articles
Influence of paternal age in assisted reproductive technology (ART) outcomes | |
Dr. Sushil Kumar Singh, Dr. Waseem Andrabi, Dr. Sonia Malik, Tabassum Hashmi | |
Background: Infertility is the inability of a person to reproduce by natural means after puberty. The present study was conducted to assess the influence of paternal age in assisted reproductive technology (ART) outcomes. Materials & Methods: A total of 726 couples who have undergone IVF treatment in Southend were considered for retrospective study and 59 patients for prospective study. We categorized the patients according to the paternal age into three groups based on their age: Group 1: <30 years, Group 2: 30-40 years and Group 3: 40-55 years. We analysed the embryological parameters like Fertilization rate, Cleavage rate, Blastocyst formation rate along with reproductive outcomes like Pregnancy rate and Implantation rates. We further subcategorised the male based on Seminal Parameters. Results: In group I, II and III, mean fertilization rate was 84.8, 84.6and 83.9. Implantation rate was 37.6, 33.1 and 26.8. Cleavage rate was 98, 97.4 and 96.9, Blastocyst rate was 52.3, 50.6 and 50.5. Live birth rate was 34.8, 31.7 and 26.4 respectively. The difference was significant (P< 0.05). Clinical pregnancy rate for group 1 (<30 years) was 65.2%, for group 2 (30-40 years) was 59.1% and for group 3 (>40 years) was 53.7%. There was no correlation of father age <30 years, 30-40 years and >40 years with mother age <35 years, >35 years and fertilization rate, implantation rate, cleavage rate, blastocyst rate, and live birth rate. Despite varying success rates across clinical pregnancy rates, none of the comparisons within each age group reached statistical significance. Conclusion: Authors did not find any significant impact of paternal age on key ART outcomes, including fertilization rate, cleavage rate, blastocyst development rate, clinical pregnancy rate, and live birth rate. However, they observed a statistically significant negative impact of paternal age on implantation rate. |
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