Background: Epidural anesthesia is a widely used technique for providing anesthesia and postoperative analgesia in various lower abdomen and lower limb surgeries. Objectives: The current study was aimed to evaluate the efficacy of dexmedetomidine and Nalbuphine as adjuvants with 0.5% ropivacaine in epidural anesthesia. The study was focused on various parameters, including the onset and duration of sensory and motor block, sedation score, and duration of postoperative analgesia. Materials and Methods: 150 eligible patients were randomly allocated in 3 groups using computerized random number table. Group C (n=50) - Ropivacaine 0.5% (18ml) + Normal saline (2ml) (Total volume-20ml), Group N (n=50) - Ropivacaine 0.5% (18ml) + Nalbuphine 200μg/kg (Total volume – 20ml), Group D (n=50) - Ropivacaine 0.5% (18ml) + Dexmedetomidine 0.75 μg/kg (Total volume 20ml). Results: Group Dpatients shows early onset of sensory block, motor block, time taken to achieve maximum sensory and motor block, along with longer duration of analgesia, compared to Group N and Group C, with statistically significant differences observed at all time points as indicated by the low p-values (p<0.001). Conclusion: dexmedetomidine is superior to Nalbuphine as an adjuvant to ropivacaine in epidural anaesthesia for better sensory and motor block characteristics and post operative pain management.