Background: An emergency laparotomy is a common surgical procedure, performed for a wide variety of intra-abdominal pathologies, which has a significant associated morbidity and mortality. Poorly managed pain after a laparotomy is a leading contributor to postoperative complications and mortality. Objectives: This study was done with the aim of comparison of postoperative analgesic efficacy of Celiac plexus block versus Thoracic epidural using Isobaric bupivacaine (0.5%) and Fentanyl in patients undergoingopen laparotomy surgery in the post operative period. Materials and Methods: In this prospective randomized double blind study, 60 patients aged between 18 – 60 years, of either sex, belonging to ASA class I and II posted for various elective laparotomy surgeries under general anaesthesia at our institute were randomly selected and divided by computer generated numbers into 2 groups with 30 patients in each group. Group C patients received celiac plexus block via direct infiltration technique at the end of surgery. Group T patients received thoracic epidural infusion after the end of surgery up to 48 hours. Conclusion: ICPB provide a good means of analgesia, decreases the post-operative stress response, improve gut motility and improve pulmonary function by providing good pain relief. It is also a simple and safe procedure which ensures an accurately placed local anesthetic solution and avoids the need for another invasive procedure for pain relief and hence can be used as an alternative to placing an epidural catheter.