Original Articles
Evaluation of Clinical and Biochemical Cardiovascular Risk Factors in Patients with Subclinical Hypothyroidism at a Tertiary Centre | |
Dr. Sumit Anand, Dr. Suresh Chaudhary, Dr. Rajendra Dhar | |
Background: An estimated 42 million people in India are thought to be afflicted with thyroid abnormalities, which are among the most prevalent endocrine diseases in the world. The present study was conducted to assess cardiac risk factors in patients with subclinical hypothyroidism. Materials & Methods: A total of 140 subjects were recruited for the study, divided into two groups- Group I (Subclinical Hypothyroidism): 70 patients diagnosed with subclinical hypothyroidism, defined as elevated TSH levels (>4.8 μiu/ml) with normal free thyroxine (ft4) levels (0.8-2.0 ng/dl) and Group II (Euthyroid Control Group): 70 subjects with normal thyroid function, defined as TSH levels within the range of 0.5-4.8 μiu/ml and normal ft4 levels (0.8-2.0 ng/dl). Results: We found that Group I consisting of 28 males and 42 females, and Group II consisting of 30 males and 40 females (p = 0.721), showing no significant difference. We found that mean BMI was 27.5 ± 3.4 kg/m² and 25.8 ± 3.1 kg/m², WHR was 0.88±0.05 and 0.85±0.04, SBP was 128.4 ± 11.2 mmHg and 122.1 ± 10.8 mmHg and DBP was 84.2 ± 7.9 mmHg and 80.3 ± 7.6 mm Hg in group I and II respectively. We found that total cholesterol was 210.4 ± 35.2 mg/dL and 185.7 ± 30.6 mg/dLmg/dL, LDL-C was 135.6 ± 29.8 mg/dL and 112.8 ± 26.4 mg/dL, HDL-C was 44.3 ± 7.1 mg/dL and 48.5 ± 8.2 mg/dL and triglyceride was 162.7 ± 38.4 mg/dL and 48.5 ± 8.2 mg/dL in group I and group II respectively. Positive correlation between TSH and LDL cholesterol in present study because Pearson’s correlation coefficient (r = 0.482). Conclusion: Heart risk variables such as blood pressure, lipid markers, and obesity indicators (BMI and WHR) are strongly correlated with subclinical hypothyroidism. |
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