Background: Mucormycosis is an opportunistic disease caused by Mucormycetes, a group of fungus. Inimmunocompromised individuals such as in diabetes mellitus, neutropenia and organ transplant recipients the fungal spores break through defence mechanism and causes severe systemic infection. During COVID-19 pandemic patients were on glucocorticoids- an immunosuppressive drug which led to high risk of Mucormycosis. Mortality rate is very high due to delay in diagnosis and treatment. Materials and methods: This study was a retrospective study conducted at Raichur Institute of medical sciences(RIMS), Raichur, Karnataka. Medical records of all the COVID-19 positive cases associated with Mucormycosis were retrieved. Clinical details along with radiological investigations were correlated with microbiology and histopathological diagnosis. A total of 109 cases were included in the study. Results: Out of the 109 cases included in the study, 86(78.89%) were male and 23(21.1%) were female patients. Majority of the cases were noted in 4th and 5th decade with 29(26.6%) patients in each category. Radiology reports were available in 29 cases which stated as acute on chronic pan sinusitis possibly fungal etiology. 6(5.5%) cases were both fungal culture and histopathology positive for mucor species and 22(20.18%) cases were negative for fungal culture and positive in histopathology diagnosis for mucor species. The reason maybe because of sparsely septate fungi and while handling/processing of biopsy entire cytoplasm oozes out and hence the organism may be lost from the tissue biopsy. Conclusion: Histopathology when compared to other techniques has advantage as it helps to identify morphology and determine host response in fungal infections. Hence histopathology can be considered as the gold standard for diagnosing mucormycosis.