Aim: This study aimed to investigate the pattern of Global Longitudinal Strain (GLS) changes following percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS)subtypes. Materials and method: In this prospective observational study, 119 patients with ACS who underwent PCI were enrolled, with 109 completing follow-up. GLS measurements were performed using 2D speckle tracking echocardiography at baseline and 12-month follow-up.Comparisons between groups were performed using Chi-square test. P value <0.05 was considered as statistically significant throughout the analysis. Results: The study population (mean age 55.32 ± 11.47 years, 84% male) showed significant differences in baseline GLS across ACS types (ST-elevation myocardial infarction (STEMI): 12.05 ± 0.239, non-ST-elevation myocardial infarction (NSTEMI): 12.99 ± 0.242, unstable angina: 13.08 ± 0.523; p=0.004). At 12-month follow-up, all groups showed improvement (STEMI: 14.76 ± 0.275, NSTEMI: 15.33 ± 0.245, unstable angina: 15.42 ± 0.647), with difference between groups no longer significant (p=0.285). The STEMI patients demonstrated the greatest GLS improvement (2.48 ± 0.113), followed by NSTEMI (2.22 ± 0.112) and unstable angina (1.62 ± 0.224; p=0.019). Conclusion: This study demonstrates significant improvements in GLS following PCI across all ACS types, with STEMI patients showing the most marked recovery despite having the lowest baseline values. These findings suggest that GLS monitoring may be valuable for assessing myocardial recovery post-PCI.