Background: In poor nations like India, self-medication with over-the-counter (OTC) or nonprescription medications is widespread.The present study was conducted to assess analgesic self- medication and its association with sleep quality among the medical students. Materials & Methods: 580 medical students of both genders. Self- medication was seen in 450 students.Parameters such as socio-demographic profile, symptoms, types of analgesics, source of information and reason for analgesic self- medication was collected. The sleep quality of students was assessed by Pittsburgh Sleep Quality Index (PSQI). Results: There were 65 males and 73 females in 1st year, 58 males and 46 females in 2nd year, 32 males and 30 females in 3rd year, 45 males and 46 females in 4th year and 20 males and 35 females in interns. The difference was significant (P< 0.05). Type of drugs used was paracetamol only in 45%, NSAIDs only in 32%, fixed dose combinations in 12% and opioids / opioid like in 11%. Sources of information was self knowledge in 60%, previous prescriptions by doctors in 15%, advertisement in 6%, chemist recommendation in 9% and advice from friends/ family in 10%. Types of symptoms/ illness was cough/ common cold/ fever was seen in 30%, headache in 46%, bone and joint pain in 14%, dysmenorrhoea in 7% and non-specific pain in 3%. The difference was significant (P< 0.05). Conclusion: Most commonly used analgesics was paracetamol alone. Most of the students had poor sleep pattern.