Background: In the emergency departments of Indian healthcare centers, acute poisoning is one of the vital medical emergencies encountered. However, existing literature data is scarce on this issue. Aim: The present study aimed to assess the epidemiological and clinical profiles of poison cases admitted to the emergency department of an Indian institute. Methods: The present study assessed the cases of poisoning admitted to the Institute within the defined study period. The study assessed a total of 1096 subjects with poisoning. All the subjects were assessed comprehensively concerning age, gender, occupation, poisoning nature, time of presentation, GCS scores, and outcomes. Results: The study results showed that the majority of the study subjects with the poisoning cases were young male subjects and were farmers by occupation. The time of presentation was more than two hours in more than half of the subjects, the GCS was low and nearly 70% of the intentional and accidental cases survived with no mortality. Sedatives and organophosphorus compounds were the common poisoning agents reported in both intentional and accidental cases of poisoning. Conclusion: The present study concludes that the present study provides insight into epidemiological and clinical knowledge to the emergency physician concerning the presentation of the subjects with poisoning and the nature of the poison in subjects reporting to the emergency department in the Indian healthcare sector.