Introduction:Histopathological examination of colorectal cancer (CRC) often interprets tumor-infiltrating lymphocytes (TILs) as the host defence mechanism preventing tumour progression. Independent of conventional prognostic markers, tumour infiltration by T cells provides a wealth of information on CRC prognosis. Immunotherapy is becoming a major tool in the fight against colorectal cancer. Melanoma, lung cancer, and colorectal cancer are only a few of the solid tumours for which TILs have shown predictive and prognostic utility. MaterialsandMethods:We went back over the records at ESIC MC and PGIMSR,Rajajinagar, Bangalore, Department of Pathology. This research includes all instances of colonectomy performed after a diagnosis of colorectal cancer. The research did not include patients who had already had neoadjuvant chemotherapy or radiation. According to the protocol, tumour sections stained with H and E were located in the archives, and lymphocytes infiltrating the tumour were counted. Results The research covered the period from January 2022 to August 2024 and comprised 30 instances of colorectal carcinomas identified from resection tissues collected by the Department of Pathology. A total of 16 girls and 14 men (a ratio of 0.875:1) participated in the research. There was a wide age range, from 35 to 74 years old, with 54 being the average. The colon had more tumors than the rectum. The score for TILs was determined. Conclusions Tumours in their advanced stages with low-grade TIL tend to have a worse prognosis. Therefore, TIL must be included in pathology reports in order to stratify patients based on risk.