Background: Vaccination is among the greatest, most successful, and cost-effective public health interventions. Vaccination remains underutilised worldwide with low vaccine uptake rates across the country with many adults remaining unprotected.This study aims to assess the perceptions and attitudes of adults toward vaccinations and identify factors influencing their willingness to vaccinate. Materials and Methods: A cross-sectional study was conducted among 200 adult participants recruited from healthcare facilities, community centers, and online platforms. A structured questionnaire was used to collect data on demographic characteristics, vaccination history, willingness to vaccinate, perceptions, attitudes, and sources of vaccine-related information. Data were analyzed using SPSS version 25.0, with descriptive statistics and multiple regression models applied to identify associations between demographic variables and vaccination willingness. Results: The majority of participants (60%) were fully vaccinated, while 25% had received partial vaccinations and 15% were unvaccinated. Willingness to receive future vaccinations was reported by 70%, whereas 15% refused, and 10% were uncertain. The primary concerns influencing vaccine hesitancy included fear of side effects (25%), lack of trust (20%), and misinformation regarding long-term health risks (15%). Healthcare providers were the most trusted source of vaccine information (70%), followed by government agencies (55%). Multiple regression analysis revealed that age (β = 0.15, p = 0.041), education level (β = 0.20, p = 0.015), healthcare access (β = 0.30, p = 0.004), and previous vaccination history (β = 0.25, p = 0.027) were significant predictors of willingness to vaccinate. Conclusion: This study highlights that while adult vaccination attitudes are generally positive, barriers such as vaccine hesitancy, misinformation, and accessibility challenges remain. Strengthening healthcare provider recommendations, enhancing vaccine education, and improving accessibility are essential strategies to increase vaccine uptake. Addressing concerns about vaccine safety and efficacy is critical to reducing hesitancy and ensuring broader public health protection.