Background: Prolonged exposure to digital screens has led to an increase in visual fatigue, commonly referred to as digital eye strain (DES). This condition encompasses symptoms such as eye discomfort, dryness, blurred vision, and headaches, significantly impacting daily productivity and well-being.Objective: This study aims to assess the prevalence and severity of visual fatigue among digital screen users, identify contributing factors such as screen time, device type, and environmental conditions, and evaluate the effectiveness of preventive measures.Methods: A cross-sectional study was conducted with 185 participants aged 18–55 years. Data were collected using a structured questionnaire to gather demographic information, screen usage patterns, and self-reported symptoms of visual fatigue. An observational checklist was used to validate environmental conditions. Data were analyzed using descriptive statistics, Pearson’s correlation, regression analysis, and chi-square tests.Results: Visual fatigue was reported by 82% of participants, with 22% experiencing severe symptoms. Common symptoms included eye discomfort (78%), dryness (65%), and blurred vision (50%). Laptops and smartphones were associated with higher symptom scores compared to desktops and tablets. Poor lighting and improper screen positioning significantly increased symptom severity. Preventive measures, such as the 20-20-20 rule and blue light filters, were effective in reducing symptoms, yet awareness and implementation of these strategies were limited.Conclusion: The study concludes that visual fatigue is a widespread concern linked to screen usage patterns and environmental factors. Increasing awareness and promoting preventive practices can mitigate symptoms and improve visual health in a screen-dependent society. Further research is recommended to explore long-term impacts and advanced interventions.