Background: Laparoscopic cholecystectomy (LC) is a common minimally invasive surgery that offers advantages like reduced hospitalization and faster recovery. However, postoperative pain management remains a critical concern, with pain originating from incision sites, pneumoperitoneum, and visceral pain. A multimodal analgesia approach combining opioids and non-opioids is often employed for effective pain relief. This study compares the efficacy of intravenous dexmedetomidine and ketorolac in providing postoperative analgesia following LC. Objective: To evaluate and compare the effectiveness of intravenous dexmedetomidine and ketorolac for postoperative pain management in patients undergoing laparoscopic cholecystectomy. Methods: A prospective, randomized, open-label study was conducted with 60 patients undergoing LC. Patients were randomly assigned to two groups: Group A (dexmedetomidine, 1 μg/kg/hr before anesthesia induction, followed by 0.5 μg/kg/hr) and Group B (ketorolac, 30 mg intravenously after induction). Pain was assessed using the Visual Analogue Scale (VAS) at 2-hour intervals postoperatively, and rescue analgesia was administered if necessary. Hemodynamic parameters (heart rate and mean arterial pressure) were monitored throughout. Results: Group A (dexmedetomidine) exhibited significantly lower VAS scores at all time points compared to Group B (ketorolac), with a p-value < 0.0001 at 24 hours postoperatively. The time to first rescue analgesia was significantly longer in Group A (9.2 ± 2.3 hours) compared to Group B (5.1 ± 1.8 hours), suggesting better pain control with dexmedetomidine. Both groups maintained stable hemodynamic parameters, and there were no major adverse events. Conclusion: Dexmedetomidine provided superior postoperative pain relief compared to ketorolac, with significantly lower pain scores and delayed need for rescue analgesia. Both drugs were well tolerated, with no significant hemodynamic instability, indicating dexmedetomidine as an effective adjunct for postoperative analgesia in laparoscopic cholecystectomy.