Objective: To assess the impact of endometriosis on women's quality of life, fertility, mental health, and daily functioning, and to identify the social and economic challenges associated with the condition.Methods: A cross-sectional study was conducted involving 230 women diagnosed with endometriosis through clinical and laparoscopic evaluation. Data were collected using validated tools, including the SF-36 Health Survey for quality of life, a fertility questionnaire, and the Hospital Anxiety and Depression Scale (HADS) for mental health. Statistical analysis involved descriptive and inferential tests, including Chi-square tests, t-tests, and correlation analyses.Results: The study found that chronic pelvic pain (85%) and fatigue (78%) were the most common symptoms, significantly impairing quality of life, with an average physical functioning score of 52. Infertility was reported by 58% of participants, with severe endometriosis strongly associated with longer infertility duration (p<0.001). Mental health assessments revealed high levels of anxiety (12.8/21) and depression (11.5/21), particularly in participants with severe disease. Additionally, 72% reported decreased sexual satisfaction, and 68% experienced financial strain due to medical expenses. Conclusion: It is concluded that endometriosis profoundly affects women's physical health, fertility, mental well-being, and socioeconomic status. Delayed diagnosis, ineffective treatment, and high financial burdens further exacerbate these challenges.