Background: Surgical site infections (SSIs) are a significant cause of morbidity and healthcare costs, particularly in abdominal surgeries. The use of antimicrobial-coated sutures has been proposed as a strategy to reduce SSIs by preventing microbial colonization at the surgical site. This study evaluates the rates of SSIs associated with conventional sutures versus antimicrobial-coated sutures in abdominal surgeries. Materials and Methods: This prospective study included 200 patients undergoing elective abdominal surgeries in a tertiary care hospital. Patients were randomized into two groups: Group A (n=100) received conventional sutures, and Group B (n=100) received antimicrobial-coated sutures. Patient demographics, surgical details, and comorbidities were recorded. SSIs were assessed based on clinical and microbiological criteria up to 30 days postoperatively. Statistical analysis was performed using the chi-square test, and a p-value <0.05 was considered significant. Results: The incidence of SSIs was significantly lower in Group B (antimicrobial-coated sutures) compared to Group A (conventional sutures). In Group A, 20% of patients developed SSIs, whereas only 8% of patients in Group B had SSIs (p=0.01). Most infections were caused by Escherichia coli and Staphylococcus aureus. The average length of hospital stay was shorter in Group B (7 days) compared to Group A (10 days). Conclusion: Antimicrobial-coated sutures significantly reduce the rate of SSIs in abdominal surgeries compared to conventional sutures. Their use may improve postoperative outcomes and reduce hospital stays, highlighting their potential as a valuable intervention in surgical practice.