Background: Acute viral infections pose significant health challenges worldwide, often leading to severe complications if not managed promptly. Early administration of antiviral therapy is hypothesized to improve clinical outcomes compared to delayed treatment. This study aims to evaluate the efficacy of early versus late administration of antiviral therapy in patients with acute viral infections. Materials and Methods: A total of 200 patients diagnosed with acute viral infections were included in this prospective study. Participants were randomly divided into two groups: the Early Treatment Group (ETG), receiving antiviral therapy within 24 hours of symptom onset, and the Late Treatment Group (LTG), receiving therapy after 72 hours. Clinical parameters, including symptom resolution time, hospitalization duration, and viral load reduction, were assessed. Statistical analyses were performed using t-tests and chi-square tests to compare outcomes between the groups, with a significance level set at p < 0.05. Results: Patients in the ETG demonstrated a significantly shorter symptom resolution time (5.2 ± 1.3 days) compared to the LTG (8.6 ± 1.7 days, p < 0.001). The duration of hospitalization was also significantly reduced in the ETG (3.8 ± 1.2 days) versus the LTG (6.1 ± 1.5 days, p < 0.001). Additionally, viral load reduction at day 5 post-treatment initiation was greater in the ETG (85%) compared to the LTG (62%, p < 0.01). No significant adverse effects were observed in either group. Conclusion: Early administration of antiviral therapy in acute viral infections significantly enhances clinical outcomes by reducing symptom resolution time, hospitalization duration, and viral load. These findings underscore the importance of initiating antiviral treatment promptly to achieve optimal therapeutic benefits.