Background: Hypothyroidism is prevalent among obese Indian women. Patients with hypothyroidism exhibit a higher prevalence of comorbidities and complications in comparison to individuals without this condition. Therefore, timely identification and treatment of hypothyroidism can effectively mitigate numerous complications in patients, particularly in cases of subclinical hypothyroidism. Aim and Objective: To study the presentation and clinical profile of hypothyroidism in Indian population. Material &Methods: This cross-sectional study was conducted among 100 patients clinically diagnosed with hypothyroidism at Department of Gen. Medicine Govt. Medical College, Bundi (Rajasthan) a tertiary care center in India. A comprehensive history and clinical examination were conducted to determine the clinical characteristics. Results: Females exhibited a greater prevalence of hypothyroidism, with a rate of 71.7%, compared to males. The predominant symptoms include fatigue, excessive weight gain, facial swelling, irritability, hair thinning, and irregular menstrual cycles. The typical observations during a general examination include weight gain, pallor, dry skin, pedal edema, and Goiter. Hypothyroidism is commonly associated with type 2 diabetes mellitus, dyslipidemia, obesity, and hypertension. Conclusions: Hypothyroidism is most prevalent in older females. The typical clinical manifestations of hypothyroidism include increased body weight, muscle weakness, swelling of the face, swelling of the lower extremities, hair loss, pale skin, and irregular menstrual cycles.