Background: CTG (Cervicothoracic ganglion) has a high surgical significance in the diagnosis and management of chronic regional pain syndromes, vascular occlusive disorders, refractory angina, and herpes zoster. CTG can be perforated with the VA (vertebral artery) which can lead to complications encountered in the ganglionic block. Aim: The present study was aimed at morphological assessment of perforated CTG (cervicothoracic ganglion) in cadavers of India. Methods: The present study assessed 50 cadavers that were embalmed in formalin comprising 14 female and 36 male cadavers. Among 50 cadavers, 4 specimens from the right side were excluded owing to damage and adhesion to the ganglion. A total of 96 specimens including 50 left and 46 right were included and assessed for perforated CTG. Results: CTG was seen in 87.5% of the specimens, whereas, inferior cervical ganglion was seen in 12.5% of the specimens. Perforated CTG was seen in 9.52% (n=8) specimens exclusively on the left side where the vertebral artery pierced at its middle or superior pole. The perforated CTG was exclusively seen on the left side, and in all 8 specimens, the vertebral artery was the branch from the subclavian artery. Conclusion: The present study concludes that analysing the morphology of perforated CTG in cadavers from India depicts the occurrence of CTG. It is vital to consider the associated risk of injury to the vertebral artery while giving a CTG block. Also, it is vital to understand the variations that could help aesthetics, surgeons, and neurosurgeons in the prevention of complications during the diagnostic and therapeutic ganglionic blocks.