Background and objectives: Finding high-risk pregnancies early on is the main problem in modern obstetrics so that the appropriate steps can be taken to lower the prevalence of the condition. This study aimed to investigate the relationship between placental position and pre-eclampsia development. Method: 120 pregnant women participated in the study, which involved taking their medical histories, performing a general and obstetric checkup with USG between weeks 18 and 24, and monitoring them until delivery to look for signs of preeclampsia and its correlation with placental position. Results: Our study shows that out of 120 women, 37% developed pre-eclampsia between 21–25 years, 22% of pre-eclamptic women delivered at 31–35 weeks of gestation, 63% of pre-eclamptic women weigh between 71–80 kg, 97 (81%) had central placenta, and 23 (19%) had lateral placenta. Pre-eclampsia developed in patients with lateral placentas (33%), and those with central placentas developed pre-eclampsia in 15%, which was statistically significant. Conclusion: Though there are many predictors for pre-eclampsia, early detection of placental location by a routine anomaly scanwill definitely be the best predictor in categorizing the woman under the high-risk group so that close fetomaternal surveillance can be done to reduce the maternal and neonatal morbidity as well as mortality.