Background: Children who have hearing loss may experience severe consequences for their speech and language development, leading to a double tragedy where they completely lose their ability to communicate naturally. The present study was study was conducted to assess outcomes of cochlear implantation in children with multiple disabilities. Materials & Methods: 104 deaf children of both genderswere divided into 2 groups of 52 each. Group I comprised of 52 deaf children with multiple disabilities and group II were deaf children without any additional disabilities. All children underwent cochlear implantation. Category of Auditory Performance (CAP) scores, Speech Intelligibility Rating (SIR) scores, and also Meaningful Auditory-Integration Scale (MAIS scores were compared at 6 months and 12 months post-implantation. Results: Group I had 32 males and 20 females and group II had 27 males and 25 females. In group I and group II, CAP score >4 pre-implantation was seen in 10%and 17%, at 6 monthswas seen in 45% and 67% and at 12 months was seen in 78% and 90% in group I and II respectively. SIR score >4 pre-implantation was seen in 15% and in 24%, at 6 months was seen in 65% and in 70%, at 12 months in 72% and 88% in group I and II respectively. MAIS score >30 pre-implantation was seen in 7% and 11%, at 6 months in 36% and 40% and at 12 months in 69% and 84% in group I and II respectively. The difference was significant (P< 0.05). Conclusion: Children with multiple disabilities who have received cochlear implantation require intensive rehabilitation, where their unique needs are met on an individual basis and maximized for the greatest result.