Background: Leprosy (Hansen’s disease) is caused by infection of susceptible individuals with acid-fast bacilli (AFB) of the Mycobacterium leprae complex (M. leprae and M. lepromatosis). Hence, the present was undertaken to analyzethe histopathological spectrum of leprosy patients.Materials &Methods:A total of 100 patients clinically diagnosed with leprosy were included in this study, all of whom underwent skin biopsy. The study materials comprised skin biopsies from individuals confirmed to have leprosy. Following processing, serial sections of the biopsy specimens were prepared, stained with Hematoxylin and Eosin for morphological evaluation, and subjected to Ziehl-Neelsen staining for bacilli identification. Histopathological characteristics were recorded, and the diagnosis of leprosy was confirmed and classified according to the Ridley and Jopling classification system.Results: Among the 100 patients evaluated, histopathological spectrum showed that lepromatous and tuberculoid type were seen in 31 percent and 25 percent of the patients respectively. Borderline tuberculoid and Borderline lepromatous type were seen in 18 percent and 13 percent of the patients respectively. Intermediate type, Histoid type and Erythema nodosum leprosum type were seen in 6 percent, 5 percent and 2 percent of the patients respectively. There were 59 males and 41 females. The mean age of the patients was 45.9 years. Non-significant results were obtained while correlating the histopathological types with age-wise and gender-wise distribution. Conclusion:It is essential to establish a correlation among clinical, histopathological, and bacteriological characteristics for the accurate diagnosis and classification of leprosy.