Background: The present study was conducted for assessing the effect of single dose dexmedetomidine given prior to extubation-on-extubation conditions in adult patients following general anesthesia. Materials & methods: Fifty adult patients, aged between 18 and 80 years, classified as American Society of Anesthesiologists physical status (ASA PS) class I-II, and representing both genders, were recruited for elective surgical procedures. The participants were randomly divided into two groups: Group A received dexmedetomidine at a dosage of 0.75 mcg/kg, while Group B was administered normal saline. Following the observation of satisfactory spontaneous respiratory efforts, neostigmine and glycopyrrolate were administered intravenously to reverse the effects of neuromuscular blockers. After the reversal, patients were gently and continuously prompted to open their eyes. Extubation occurred when patients responded to verbal stimuli by opening their eyes and demonstrated normal respiratory function, with the time of extubation recorded as TE. Subsequently, all patients were moved to the post-anesthetic care unit (PACU) post-surgery. Occurrences of postoperative nausea, vomiting (PONV), and shivering were documented. Results: Mean age of the patients of group A and group B was 39.2 years and 41.7 years respectively. There were 16 males and 9 females in group A and there were 18 males and 7 females in group B. Majority proportion of patients of both the study groups were of ASA grade A and Grade B. No significant difference was obtained while comparing the MAP among the patients of the two study groups at different time intervals. However; heart rate showed significant difference at 3 mins and 6 mins among the two study groups. Incidence of PONV was significantly higher among patients of group B. Conclusion: An administration of dexmedetomidine prior to extubation did not influence the intensity of coughing; however, it led to enhanced hemodynamic stability at specified intervals following extubation.