Background: Chronic liver disease (CLD) is often associated with alterations in liver function and thyroid profiles. Aim: Therefore, the present study aimed to evaluate and compare liver function and thyroid profile parameters in patients with chronic liver disease and healthy controls. Methods: A case-control study was conducted at the Maharishi Markandeshwar Institute of Medical Sciences and Research (MMIMSR), Mullana, Ambala, from 2019 to 2021. The study assessed various liver function and thyroid profile parameters, including Bilirubin, SGPT, SGOT, T3, T4, FT3, FT4, and TSH. Blood samples were collected for biochemical analysis, and statistical significance was determined using t-tests and Pearson’s correlation. Results: Liver function parameters (Bilirubin, SGPT, SGOT) were significantly higher in cases compared to controls (p < 0.01 for all). Bilirubin was 2.45 ± 0.61 in cases vs. 0.96 ± 0.19 in controls, SGPT was 52.05 ± 7.51 vs. 27.35 ± 7.43, and SGOT was 48.31 ± 6.96 vs. 32.45 ± 7.78. Thyroid profile parameters, including T3, T4, FT3, FT4, and TSH, were significantly lower in cases (p < 0.01). Correlation analysis revealed a moderate negative correlation between Bilirubin and thyroid function (r = -0.46, p = 0.003), and a positive correlation between SGOT and thyroid function (r = 0.38, p = 0.014). SGPT showed a weak non-significant correlation (r = 0.27, p = 0.091). Discussion & Conclusion: This study demonstrates significant alterations in liver function and thyroid profile parameters in patients with chronic liver disease compared to controls. The findings highlight the potential interaction between liver function and thyroid status, suggesting that thyroid dysfunction may be an important consideration in the management of chronic liver disease.