Introduction: Accurate characterization of liver lesions is crucial for optimal patient management. Magnetic Resonance Imaging (MRI) has emerged as a powerful non-invasive tool for liver lesion evaluation. This study aimed to assess the diagnostic accuracy of MRI in characterizing liver lesions through correlation with histopathological findings. Methods: A prospective, observational study was conducted over 6 months, involving 150 patients with liver lesions. All patients underwent 3T MRI examinations including T1-weighted, T2-weighted, diffusion-weighted, and dynamic contrast-enhanced sequences. Two radiologists independently analyzed the MRI images, and their findings were correlated with histopathological results. Statistical analysis included diagnostic accuracy measures, inter-observer agreement, and multivariate analysis of predictive MRI features. Results: MRI demonstrated high diagnostic performance with 92.3% sensitivity, 88.7% specificity, and 90.7% overall accuracy in characterizing liver lesions. Strong inter-observer agreement was observed for most MRI features (κ = 0.79-0.92). Significant differences in ADC values were found between benign (1.85 ± 0.42 × 10⁻³ mm²/s) and malignant (1.12 ± 0.31 × 10⁻³ mm²/s) lesions (p<0.001). Multivariate analysis identified delayed washout (OR = 5.1), diffusion restriction (OR = 4.2), and arterial enhancement (OR = 3.5) as the strongest predictors of malignancy. Conclusion: MRI demonstrates excellent diagnostic accuracy in characterizing liver lesions, with strong correlation to histopathological findings. The identified predictive imaging features and quantitative parameters provide a robust framework for non-invasive lesion assessment, supporting the central role of MRI in the diagnostic algorithm for liver lesions.