Aim: To evaluate the effectiveness of a multidisciplinary care approach in managing ear, nose, and throat (ENT) disorders in patients with cardiovascular diseases (CVDs). Material and Methods: This prospective study included 130 adult patients with newly diagnosed ENT conditions (e.g., chronic rhinosinusitis, otitis media, or dysphagia) and pre-existing or newly diagnosed cardiovascular diseases (e.g., hypertension, coronary artery disease, or arrhythmias). A multidisciplinary team comprising otolaryngologists, cardiologists, and other specialists developed individualized treatment plans integrating pharmacological, non-pharmacological, and surgical interventions. Data were collected on baseline characteristics, diagnostic evaluations, treatment modalities, and outcomes, including symptom improvement, cardiovascular stability, and quality of life. Results: The study demonstrated significant improvements in ENT symptoms, with the mean symptom score decreasing from 6.8 ± 2.1 to 3.2 ± 1.4 (p < 0.001). Quality of life scores (EQ-5D) improved from 52.4 ± 9.3 to 71.6 ± 12.8 (p < 0.001). Cardiovascular stability was enhanced, with blood pressure decreasing from 144/92 ± 12/8 mmHg to 130/84 ± 10/6 mmHg (p < 0.001), and the absence of cardiovascular events increased from 86.15% to 96.92% (p = 0.008). Multidisciplinary care (β = 0.384, p < 0.001) and adherence to treatment (β = 0.512, p < 0.001) were significant predictors of positive outcomes. Conclusion: Multidisciplinary care significantly improved ENT symptoms, cardiovascular stability, and quality of life in patients with coexisting ENT and cardiovascular conditions. Collaborative care and patient adherence were crucial determinants of success, underscoring the importance of integrating multidisciplinary approaches in managing complex comorbidities.