Background: The methods for accurately and promptly diagnosing fetal abnormalities have advanced significantly during the past 20 years. The present study compared the pregnancy outcome following amniocentesis at 14 weeks of gestation with the pregnancy outcome following later amniocentesis and CVS. Materials &Methods: 48 women who underwent invasive prenatal diagnostic procedureswere classified into 3 groups of 18 each. Group I underwent amniocentesis at 14 weeks of gestation, group II amniocentesis at ≥15 weeks of gestation and group III underwent chorionic villous sampling. The pregnancy outcomes and the complications were compared. Results: Parity 0 was seen in 7, 6 and 4in group I, II and III respectively. Parity +1 in 11, 12 and 14 respectively. Previous miscarriage was 0 in 10, 7 and 8, 1 in 4, 5 and 5 and +1in 4, 6 and 5 patients. Placental site was anterior in 7, 7 and 9, posterior in 8, 7 and 6 and other fundal in 3, 4 and 3. Indication was NT risk > 1:300 in 3, 1 and 2, maternal anxiety in 7, 9 and 6, maternal age in 4, 6 and 7 and previous history in 4, 2 and 3patients respectively. The difference was non- significant (P>0.05). Outcomes in group I, group II and group III was failed culture in 1, 0 and 1, failed procedure in 1, 1 and 2, amniotic fluid leakage in 2, 1 and 1, blood stained liquor in 0, 1 and 2, PPROM in 1, 2 and 0, bleeding in 1, 1 and 0, respiratory complication in 1, 1 and 2, preterm delivery in 2, 1, 2 and blood stained liquor in 2, 2, 1 respectively. The difference was non- significant (P>0.05). Conclusion: Women could be administered amniocentesis at 14 weeks of gestation as an alternative to later amniocentesis or CVS without posing a noticeably higher risk to the mother and unborn child.