Objective: This study aimed to compare the effectiveness of norepinephrine monotherapy with the combination of norepinephrine and vasopressin in the management of hemorrhagic shock. Methodology: Retrospective observational research was conducted on 200 patients of age 25 years and above and were diagnosed with hemorrhagic shock. Patients were divided into two groups: 100 patients receiving norepinephrine monotherapy and the other 100 receiving a combination of norepinephrine and vasopressin. Hemodynamic parameters, including mean arterial pressure, heart rate, and lactate levels, were recorded at baseline and after 24 hours. Clinical outcomes, such as organ dysfunction, mortality rates, and duration of stay in the intensive care unit, were meticulously evaluated. A suite of statistical analyses, including independent t-tests, Mann-Whitney U tests, chi-square tests, and multivariate regression models, was employed to compare outcomes between the two groups, with statistical significance defined at a threshold of p < 0.05. Results: Both therapeutic approaches demonstrated efficacy in enhancing hemodynamic parameters. The cohort receiving the combination therapy exhibited a marginally higher mean arterial pressure (MAP) at 24 hours compared to the monotherapy group, with statistical significance (p = 0.04). However, no notable differences were identified between the two groups concerning mortality rates (p = 0.68), the incidence of organ dysfunction (p = 0.72), or the duration of ICU stay (p = 0.56). Multivariate regression analysis further substantiated that neither treatment regimen exerted a significant independent influence on clinical outcomes after adjusting for potential confounding variables. Conclusion:The study concluded that both norepinephrine monotherapy and the combined regimen of norepinephrine with vasopressin were effective in achieving hemodynamic stabilization in patients with hemorrhagic shock. However, the inclusion of vasopressin did not provide a discernible benefit regarding mortality rates, the incidence of organ dysfunction, or the duration of intensive care unit stay.