Background: One of the main reasons people attend the emergency department (ED) is hypoglycemia. Additionally, it is the most prevalent and readily avoidable endocrine emergency. The present study was conducted to assess clinical profile of hypoglycemic patients in emergency department. Materials & Methods: 76 patients of hypoglycaemia of both genders were included. Assessment of blood glucose concentration was determined by Accu-Check Gluco-stix. Results: Themean age was 57.1 years, HGT was 45.2, pulse was 90.2 beats per minute, systolic blood pressure was 132.5 mm Hg, diastolic blood pressure was 79.2 mm Hg and GCS was 10.5. Common symptoms were anorexia in 51, fever in 42, LOC in 59, fall in 37, AMS in 23, FND in 5, syncope in 12 and others in 10 cases. The difference was significant (P< 0.05). Common causes were OHA in 40, OHA+ insulin in 19, insulin in 7, others in 5, skipped meal in 4 and alcohol in 3 cases. The difference was significant (P< 0.05). Conclusion: When hypoglycemia is severe enough to warrant ED visits, it increases the risk of major events and unfavorable outcomes for people with diabetes. This is true for both insulin treatment and non-insulin glucose-lowering medications.