Background:Cholecystitis is a condition that typically requires surgical intervention, with laparoscopic cholecystectomy being the most common treatment approach. Effective management of post-operative pain is a critical aspect of the care provided to surgical patients. The present study was conducted for comparative evaluation of postoperative pain relief following spinal and general anesthesia in patients undergoing laparoscopic cholecystectomy. Materials &Methods: A total of 100 patients scheduled to undergo LC were enrolled.Complete demographic and clinical details of all the patients were obtained. Randomization was done of all the patients into two study groups with 50 patients in each group as follows: Group A: Patients undergoing LC under spinal anesthesia, and Group B: Patients undergoing LC under general anesthesia. Post-operative pain was assessed. Chi-square test and student t test was used for evaluation of level of significance. P-value < 0.05 was considered as significant. Results: Mean age of the patients of group A and group B was 45.8 years and 42.9 years respectively. Significant results were obtained while comparing the pain at the end of the surgery among the patients of the two study groups. However; while comparing the postoperative pain 6 hours after the surgery among the two study groups, non-significant results were obtained. Conclusion:In patients who have undergone laparoscopic cholecystectomy, spinal anesthesia is associated with superior postoperative analgesia during the recovery phase.