Background: The neurodevelopmental illness known as attention-deficit hyperactivity disorder (ADHD) is typified by recurrent patterns of impulsivity, hyperactivity, and inattention that impede daily functioning and growth. The present study was conducted to evaluate adult attention deficit hyperactivity disorders among patients with opioid-dependence syndrome. Materials & Methods: 112 patients with opioid-dependence syndromeof both genders were selected. The Mini International Neuropsychiatric Interview 5.0, the Maudsley Addiction Profile, and the adult ADHD self-report screening scale were used to evaluate the patients. A range of sociodemographic, drug use, and clinical variables were examined between those who tested positive for adult ADHD (ADHD+) and those who tested negative (ADHD−). Results: Education level was primary level in 68 and secondary level in 44. Family type was alone in 83 and nuclear in 29. Marital status was unmarried/separated/divorced in 61, married/widowed in 51 subjects. Type of opioid use was heroin in 32, natural opioid (opium etc.) in 40, prescription opioids in 22 and mixed in 18 subjects. Comorbid substance use was alcohol dependence in 10, cannabis dependence in 16, sedative/hypnotic dependence in 34, and nicotine dependence in 52 subjects. The difference was significant (P< 0.05). In ADHD positive and ADHD negative patients, mean COWS score was 1.82 and 1.18 respectively. The mean physical health score was 16.3 and 14.1. The mean anxiety score was 6.1 and 4.3. The mean depression score was 8.5 and 5.6 respectively. The difference was significant (P< 0.05). Conclusion: Adult attention deficit hyperactivity disorders were highly prevalent in opioid-dependence syndrome patients.