Aim: The Aim Of This Study Was To Investigate The Variation Of Platelet Indices Among Patients With Type 2 Diabetes Mellitus (T2DM) And Assess Their Potential Relationships With Clinical Parameters Such As Glycemic Control (Hba1c), Fasting Blood Glucose (FBG), And Body Mass Index (BMI). The Study Also Sought To Explore The Influence Of Comorbid Conditions And Diabetic Complications On Platelet Function. Materials And Methods: This Cross-Sectional Study Involved 200 Patients Diagnosed With T2DM Who Attended The Outpatient Department Of A Tertiary Care Hospital. Participants Were Selected Based On Inclusion Criteria Of Being Adults Aged 40–70 Years, With Stable Diabetic Medication Regimens For At Least Three Months. Exclusion Criteria Included Type 1 Diabetes, Pregnancy, And Patients With Hematological Or Other Disorders Affecting Platelet Function. Data Collected Included Demographic Characteristics, Clinical Parameters, And Laboratory Measurements, Including Platelet Indices (PLT, MPV, PDW, PCT) Assessed Using An Automated Hematologyanalyzer. Additional Tests For Hba1c, FBG, Lipid Profile, Liver Function, And Renal Function Were Performed. Results: The Mean Age Of Participants Was 56.8 ± 7.2 Years, With A Moderate Glycemic Control Level (Mean Hba1c = 8.2 ± 1.1%). The Platelet Indices Showed No Significant Association With Glycemic Control; The Mean PLT Was 300.8 ± 60.1 ×10³/µl, MPV Was 10.8 ± 1.6 Fl, And PDW Was 14.3 ± 2.0%. Platelet Aggregation (PA) Had A Mean Of 75.5 ± 5.2%, And Platelet Activation (PACT) Was 68.3 ± 7.1%. Laboratory Parameters Including Total Cholesterol (210 ± 35 Mg/Dl), LDL (120 ± 40 Mg/Dl), And Serum Creatinine (1.2 ± 0.3 Mg/Dl) Were Significantly Correlated With Diabetes. Regression Analysis Revealed That Platelet Count And Platelet Distribution Width Were Positively Associated With Hba1c And BMI, Whereas MPV Showed A Negative Relationship With Glycemic Control. Conclusion: This Study Demonstrates That Platelet Indices Exhibit Variations In Patients With T2DM, Although The Correlations With Glycemic Control Were Weak. Platelet Aggregation And Platelet Distribution Width Showed More Significant Associations With Clinical Parameters. These Findings Emphasize The Importance Of Monitoring Platelet Function In T2DM Patients To Better Assess Disease Progression And Cardiovascular Risk. Further Research Is Needed To Fully Elucidate The Clinical Implications And Underlying Mechanisms Of Platelet Function In Diabetes.