Background: Age-related neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and dementia, are increasing global health challenges. Existing pharmacological treatments provide symptomatic relief but often fail to address the underlying pathophysiology. Indian spices, traditionally used in culinary and medicinal practices, contain bioactive compounds with potential neuroprotective properties.Aim: To evaluate the pharmacotherapeutic potential of common Indian spices in mitigating age-related neurological disorders and their role as adjunctive therapies.Methods: This retrospective observational study was conducted at Patna Medical College over one year, involving 200 participants with age-related neurological disorders. Participants were categorized into three groups (low, medium, high spice consumption) based on dietary records. Neurological improvement was assessed using clinical notes and cognitive scores (MMSE). Statistical analysis was performed using SPSS version 23.0 to identify correlations between spice consumption and outcomes.Results: Participants in the high spice consumption group demonstrated significant neurological improvement (83.3%) compared to medium (56.3%) and low (33.3%) consumption groups (p < 0.001). Turmeric, containing curcumin, showed the strongest neuroprotective effects, followed by ginger, cinnamon, and garlic. Cognitive function also improved significantly in the high spice consumption group, with a mean MMSE score increase of +3.5 points (p < 0.001).Conclusion: The study highlights the potential of spices like turmeric, ginger, cinnamon, and garlic in reducing neuroinflammation, oxidative stress, and cognitive decline in age-related neurological disorders. High spice consumption was associated with significant improvement in clinical and cognitive outcomes.Recommendations: Further prospective studies and clinical trials are needed to explore the mechanisms underlying these findings and to standardize spice-based interventions. Integrating such dietary strategies with existing treatments may provide an affordable and culturally acceptable approach to managing neurological disorders.