Introduction-Hyperbilirubinemia is a common medical condition in neonates. It becomes problematic when bilirubin levels go to abnormally high levels and result in neurological problems. The present study was conducted to evaluate the prognostic significance of cord blood bilirubin and albumin for substantial newborn hyperbilirubinemia. Material and methods-Over the course of a year, the prospective observational study was carried out in the department of pediatrics among 108 healthy term neonates. They were monitored daily for jaundice symptoms until they were five days or until they were released from the hospital. According to Kramer's rule, venous blood was sent for bilirubin measurement if clinical icterus was found within 72 hours of birth or at any time after. A p-value of less than 0.05 was deemed statistically significant. Results-Hyperbilirubinemia was detected in 23.18% of the 108 individuals in the current investigation. There were more male patients (60%) than female patients (40%). Bilirubin levels were over 2.5 mg/dL in 42.3% of cases, below 2.5 mg/dL in 17.1% of cases, and above 2 mg/dL in 32.6% of cases and below 2 mg/dL in 15.2% of cases. With a p-value of less than 0.001, the correlation between the UCB cut-off of 2.5 mg/dL and the UCB cut-off of 2 mg/dL to predict neonatal hyperbilirubinemia was highly statistically significant.77.2% of patients had albumin levels above 3.2 and 9.3% had albumin levels below 3.2, while 51.1% of patients had albumin levels above 3 and 3.2% had albumin levels below 3. With both albumin cut-offs of 3 and 3.2, there was a statistically significant connection between albumin and neonatal hyperbilirubinemia (p-value <0.001). Sensitivity and specificity of UCB was greater than UCA. Conclusion-Neonatal hyperbilirubinemia can be predicted well by both UCB and UCA, However UCB is a stronger predictor than UCA.