Introduction: The most prevalent benign tumor of the female reproductive system, uterine fibroids (UFs) pose а serious threat to the health for women who are of reproductive age. The intervention can be hormonal or non-hormonal. Due to limited literature on the non-hormonal management of UF, there was a clear need to evaluate the effect of non-hormonal intervention in the management of symptoms commonly attributed to fibroids. Aim and Objectives: This study was done to evaluate the efficacy and safety of non-hormonal treatment in medical management of fibroid with the secondary objective to identify the cost-effectiveness and side effects. Methodology: A hospital based prospective study was done among 200 patients of symptomatic fibroid with size ≤ 6cm size. Detailed history, examination, blood investigations and baseline ultrasound examination were done. Follow-up was done at 3 months and 6 months for ultrasound, ultrasonography and whole-body check-up. The data collected was subjected to statistical analysis. Result: Before intervention, uterine fibroid size was approximately 5.90 which reduced significantly after 3 months and 6 months in subserous and intramural but no significant change was reported in submucous. At baseline; mean PBAC score was 153.56 which reduced to 84.91 and 61.03 after 3 and 6 months respectively with statistically significant difference (p<0.05). At baseline; mean VAS was 2.76 which reduced to 1.21 and 0.40 after 3 and 6 months respectively with statistically significant difference (p<0.05). Before intervention, uterine fibroid volume was approximately 22.5. After 3 months and 6 months of intervention, volume was reduced significantly in subserous and intramural but no significant change was reported in submucous. After intervention, fibroid size and volume was reduced by 89% and 87.5% respectively. Conclusion: Non-Hormonal drugs were found to be useful and effective in reducing sign and symptoms and thus general condition of the women. Tripterygium Wilfordii with vitamin D showed a promising effect as it showed a reversible inhibitory effect on ovary with minimal side effects. It was seen that it was cost effective. In this study, we have calculated sign and symptoms score and it was seen that good and mild effect was seen in 58% and 34% respectively while no effect in 8%.