Background: Infected nonunion fractures pose significant treatment challenges. The problems in treating them are infection, instability and deformity. This study evaluates the effectiveness of antibiotic cement impregnated intramedullary nails in managing infected fractures of the femur and tibia. Methods: A prospective study was conducted on 20 patients with infected fractures of the femur and tibia treated with antibiotic cement-coated intramedullary nails in Pt. J.N.M Medical College & Dr. B.R.A.M Hospital, Raipur.There were 19 males and 1 female, with mean age being The primary outcome was infection control, and the secondary outcome was bony union. Results: Infection control was achieved in 90% of cases, and bony union was observed in 80% of patients within an average of 30 weeks. Conclusion: Antibiotic cement impregnated intramedullary nailing is effective in managing infected fractures, providing both infection control and promoting bony union.